Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation.

ABSTRACT: Humoral immunity is characterized by the generation of Ab-secreting plasma cells and memory B cells that can more rapidly generate specific Abs upon Ag exposure than their naive counterparts. To determine the intrinsic differences that distinguish naive and memory B cells and to identify pathways that allow germinal center B cells to differentiate into memory B cells, we compared the transcriptional profiles of highly purified populations of these three cell types along with plasma cells isolated from mice immunized with a T-dependent Ag. The transcriptional profile of memory B cells is similar to that of naive B cells, yet displays several important differences, including increased expression of activation-induced deaminase and several antiapoptotic genes, chemotactic receptors, and costi

SUBMITTER: Bhattacharya D 

PROVIDER: S-EPMC4517294 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature