The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial.

ABSTRACT:

Background

Paracetamol's (APAP) mechanism of action suggests the implication of supraspinal structures but no neuroimaging study has been performed in humans.

Methods and results

This randomized, double-blind, crossover, placebo-controlled trial in 17 healthy volunteers (NCT01562704) aimed to evaluate how APAP modulates pain-evoked functional magnetic resonance imaging signals. We used behavioral measures and functional magnetic resonance imaging to investigate the response to experimental thermal stimuli with APAP or placebo administration. Region-of-interest analysis revealed that activity in response to noxious stimulation diminished with APAP compared to placebo in prefrontal cortices, insula, thalami, anterior cingulate cortex, and periaqueductal gray matter.

Conclus

SUBMITTER: Pickering G 

PROVIDER: S-EPMC4517518 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature