Representing virus-host interactions and other multi-organism processes in the Gene Ontology.

ABSTRACT:

Background

The Gene Ontology project is a collaborative effort to provide descriptions of gene products in a consistent and computable language, and in a species-independent manner. The Gene Ontology is designed to be applicable to all organisms but up to now has been largely under-utilized for prokaryotes and viruses, in part because of a lack of appropriate ontology terms.

Methods

To address this issue, we have developed a set of Gene Ontology classes that are applicable to microbes and their hosts, improving both coverage and quality in this area of the Gene Ontology. Describing microbial and viral gene products brings with it the additional challenge of capturing both the host and the microbe. Recognising this, we have worked closely with annotation groups to test and op

SUBMITTER: Foulger RE 

PROVIDER: S-EPMC4517558 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature