Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort.

ABSTRACT:

Background

Few studies have examined the association between obesity and markers of kidney injury in a chronic kidney disease population. We hypothesized that obesity is independently associated with proteinuria, a marker of chronic kidney disease progression.

Study design

Observational cross-sectional analysis.

Setting & participants

Post hoc analysis of baseline data for 652 participants in the African American Study of Kidney Disease (AASK).

Predictors

Obesity, determined using body mass index (BMI).

Measurements & outcomes

Urine total protein-creatinine ratio and albumin-creatinine ratio measured in 24-hour urine collections.

Results

AASK participants had a mean age of 60.2 ± 10.2 years and serum creatinine level of 2.3 ± 1.5 mg/dL; 61.3% were

SUBMITTER: Toto RD 

PROVIDER: S-EPMC4517588 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature