Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.

ABSTRACT:

Importance

Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is still unclear because amyloid plaques also occur in patients with non-AD dementia.

Objective

To use individual participant data meta-analysis to estimate the prevalence of amyloid positivity on PET in a wide variety of dementia syndromes.

Data sources

The MEDLINE and Web of Science databases were searched from January 2004 to April 2015 for amyloid PET studies.

Study selection

Case reports and studies on neurological or psychiatric diseases other than dementia were excluded. Corresponding authors of eligible cohorts were invited to provide individual participant data.

SUBMITTER: Ossenkoppele R 

PROVIDER: S-EPMC4517678 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature