Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation.

ABSTRACT: The mechanisms controlling cortical dendrite initiation and targeting are poorly understood. Multiphoton imaging of developing mouse cortex reveals that apical dendrites emerge by direct transformation of the neuron's leading process during the terminal phase of neuronal migration. During this ∼110 min period, the dendritic arbor increases ∼2.5-fold in size and migration arrest occurs below the first stable branch point in the developing arbor. This dendritic outgrowth is triggered at the time of leading process contact with the marginal zone (MZ) and occurs primarily by neurite extension into the extracellular matrix of the MZ. In reeler cortices that lack the secreted glycoprotein Reelin, a subset of neurons completed migration but then retracted and reorganized their arbor in a tangenti

SUBMITTER: O'Dell RS 

PROVIDER: S-EPMC4518046 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature