Expression and characterization of three Aurora kinase C splice variants found in human oocytes.

ABSTRACT: Chromosome segregation is an extensively choreographed process yet errors still occur frequently in female meiosis, leading to implantation failure, miscarriage or offspring with developmental disorders. Aurora kinase C (AURKC) is a component of the chromosome passenger complex and is highly expressed in gametes. Studies in mouse oocytes indicate that AURKC is required to regulate chromosome segregation during meiosis I; however, little is known about the functional significance of AURKC in human oocytes. Three splice variants of AURKC exist in testis tissue. To determine which splice variants human oocytes express, we performed quantitative real-time PCR using single oocytes and found expression of all three variants. To evaluate the functional differences between the variants, we created

SUBMITTER: Fellmeth JE 

PROVIDER: S-EPMC4518136 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature