Transient brain activity disentangles fMRI resting-state dynamics in terms of spatially and temporally overlapping networks.

ABSTRACT: Dynamics of resting-state functional magnetic resonance imaging (fMRI) provide a new window onto the organizational principles of brain function. Using state-of-the-art signal processing techniques, we extract innovation-driven co-activation patterns (iCAPs) from resting-state fMRI. The iCAPs' maps are spatially overlapping and their sustained-activity signals temporally overlapping. Decomposing resting-state fMRI using iCAPs reveals the rich spatiotemporal structure of functional components that dynamically assemble known resting-state networks. The temporal overlap between iCAPs is substantial; typically, three to four iCAPs occur simultaneously in combinations that are consistent with their behaviour profiles. In contrast to conventional connectivity analysis, which suggests a negative

SUBMITTER: Karahanoglu FI 

PROVIDER: S-EPMC4518303 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature