Ontology highlight
ABSTRACT:
SUBMITTER: Taylor MRG
PROVIDER: S-EPMC4518479 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cell 20150701 2
Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes strand exchange with homologous duplex DNA. BRCA2 and the Rad51 paralogs are tumor suppressors and critical mediators of Rad51. To gain insight into Rad51 paralog function, we investigated a heterodimeric Rad51 paralog complex, RFS-1/RIP-1, and uncovered the molecular basis by which Rad51 paralogs promote HR. Unlike BRCA2, which nucleates R ...[more]