Ontology highlight
ABSTRACT:
SUBMITTER: Topham C
PROVIDER: S-EPMC4518499 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cancer cell 20150701 1
Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer. Using time-lapse imaging to correlate mitotic behavior with cell fate, we show that Myc sensitizes cells to mitotic blockers and agents that accelerate mitotic progression. Myc achieves this by upregulating a cluster of redundant pro-apoptotic BH3-on ...[more]