Influence of ethnicity on the distribution of genetic polymorphisms associated with risk of chronic liver disease in South American populations.

ABSTRACT:

Background

The global burden of chronic liver disease is rising. Besides environmental, behavioral, viral and metabolic factors, genetic polymorphisms in patatin-like phospholipase-3 (PNPLA3) and vitamin D receptor (VDR) genes have been related to the development of chronic liver disease and progression towards liver cancer. Although their prevalence differs remarkably among ethnic groups, the frequency of these polymorphisms in South American populations -whose genetic background is highly admixed- has been poorly studied. Hence, the aim of this study was to characterize polymorphisms related to chronic liver disease and their association with the genetic ancestry of South American populations.

Results

DNA samples from 258 healthy unrelated male volunteers were analyzed. Th

SUBMITTER: Pontoriero AC 

PROVIDER: S-EPMC4518515 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature