Inferring 3D chromatin structure using a multiscale approach based on quaternions.

ABSTRACT:

Background

The knowledge of the spatial organisation of the chromatin fibre in cell nuclei helps researchers to understand the nuclear machinery that regulates DNA activity. Recent experimental techniques of the type Chromosome Conformation Capture (3C, or similar) provide high-resolution, high-throughput data consisting in the number of times any possible pair of DNA fragments is found to be in contact, in a certain population of cells. As these data carry information on the structure of the chromatin fibre, several attempts have been made to use them to obtain high-resolution 3D reconstructions of entire chromosomes, or even an entire genome. The techniques proposed treat the data in different ways, possibly exploiting physical-geometric chromatin models. One popular strategy is

SUBMITTER: Caudai C 

PROVIDER: S-EPMC4518643 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature