Network analysis of temporal functionalities of the gut induced by perturbations in new-born piglets.

ABSTRACT:

Background

Evidence is accumulating that perturbation of early life microbial colonization of the gut induces long-lasting adverse health effects in individuals. Understanding the mechanisms behind these effects will facilitate modulation of intestinal health. The objective of this study was to identify biological processes involved in these long lasting effects and the (molecular) factors that regulate them. We used an antibiotic and the same antibiotic in combination with stress on piglets as an early life perturbation. Then we used host gene expression data from the gut (jejunum) tissue and community-scale analysis of gut microbiota from the same location of the gut, at three different time-points to gauge the reaction to the perturbation. We analysed the data by a new combinati

SUBMITTER: Benis N 

PROVIDER: S-EPMC4518884 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature