Predictive Factors for BRCA1 and BRCA2 Genetic Testing in an Asian Clinic-Based Population.

ABSTRACT:

Purpose

The National Comprehensive Cancer Network (NCCN) has proposed guidelines for the genetic testing of the BRCA1 and BRCA2 genes, based on studies in western populations. This current study assessed potential predictive factors for BRCA mutation probability, in an Asian population.

Methods

A total of 359 breast cancer patients, who presented with either a family history (FH) of breast and/or ovarian cancer or early onset breast cancer, were accrued at the National Cancer Center Singapore (NCCS). The relationships between clinico-pathological features and mutational status were calculated using the Chi-squared test and binary logistic regression analysis.

Results

Of 359 patients, 45 (12.5%) had deleterious or damaging missense mutations in BRCA1 and/or BRCA2. BRCA

SUBMITTER: Wong ES 

PROVIDER: S-EPMC4519264 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature