Somatostatin Improved B Cells Mature in Macaques during Intestinal Ischemia-Reperfusion.

ABSTRACT:

Aims

Intestinal ischemia-reperfusion has been taken as an important pathophysiological process for multiple organ dysfunctions in critical patients. Recent studies reported that dual expression programs of the B cells receptors and Toll-like receptors on B-lymphocytes permit these ubiquitous cells to integrate both adaptive and innate immune functions. Our previous studies found that somatostatin inhibited the intestinal inflammatory injury after ischemia-reperfusion in macaques. However, the changes of B cells and the effects of somatostatin on B cells after intestinal ischemia-reperfusion were unclear.

Methods

15 macaques were divided into control, intestinal ischemia-reperfusion and somatostatin pretreatment groups. Immunohistochemistry was performed to identify the distr

SUBMITTER: Liu L 

PROVIDER: S-EPMC4519283 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature