The Esg Gene Is Involved in Nicotine Sensitivity in Drosophila melanogaster.

ABSTRACT: In humans, there is a strong correlation between sensitivity to substances of abuse and addiction risk. This differential tolerance to drugs has a strong genetic component. The identification of human genetic factors that alter drug tolerance has been a difficult task. For this reason and taking advantage of the fact that Drosophila responds similarly to humans to many drugs, and that genetically it has a high degree of homology (sharing at least 70% of genes known to be involved in human genetic diseases), we looked for genes in Drosophila that altered their nicotine sensitivity. We developed an instantaneous nicotine vaporization technique that exposed flies in a reproducible way. The amount of nicotine sufficient to "knock out" half of control flies for 30 minutes was determined and thi

SUBMITTER: Sanchez-Diaz I 

PROVIDER: S-EPMC4519288 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature