Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations.

ABSTRACT: The mammalian liver plays a key role for metabolism and detoxification of xenobiotics in the body. The corresponding biochemical processes are typically subject to spatial variations at different length scales. Zonal enzyme expression along sinusoids leads to zonated metabolization already in the healthy state. Pathological states of the liver may involve liver cells affected in a zonated manner or heterogeneously across the whole organ. This spatial heterogeneity, however, cannot be described by most computational models which usually consider the liver as a homogeneous, well-stirred organ. The goal of this article is to present a methodology to extend whole-body pharmacokinetics models by a detailed liver model, combining different modeling approaches from the literature. This approach r

SUBMITTER: Schwen LO 

PROVIDER: S-EPMC4519332 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature