Endothelial progenitor cell phenotype and function are impaired in childhood-onset systemic lupus erythematosus.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) is characterized by increased cardiovascular risk in adult-onset and childhood-onset SLE. Type I interferons (IFNs) appear to play a prominent role in premature vascular damage in adult-onset SLE, at least in part, by inducing impairments in the phenotype and function of endothelial progenitor cells (EPCs), thereby hampering vascular repair. It is not clear whether EPC dysfunction is present in childhood-onset SLE in association with a type I IFN signature.

Methods

The phenotype and numbers of EPCs were quantified in patients with childhood-onset SLE, patients with juvenile idiopathic arthritis (JIA), and matched healthy control subjects. In a separate cohort of patients with childhood-onset SLE, markers of subclinical atheroscler

SUBMITTER: Mohan S 

PROVIDER: S-EPMC4519391 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature