Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener's).

ABSTRACT:

Objective

To determine whether disease processes related to granulomatosis with polyangiitis (Wegener's) (GPA) are reflected in gene expression profiles of the nasal mucosa.

Methods

Nasal brushings of the inferior turbinate were obtained from 32 patients with GPA (10 with active nasal disease, 13 with prior nasal disease, and 9 with no history of nasal disease) and a composite comparator group with and without inflammatory nasal disease (12 healthy people, 15 with sarcoidosis, and 8 with allergic rhinitis). Differential gene expression was assessed between subgroups of GPA and comparators.

Results

A total of 339 genes were differentially expressed between the GPA and comparator groups (absolute fold change >1.5; false discovery rate <0.05). Top canonical pathways up-r

SUBMITTER: Grayson PC 

PROVIDER: S-EPMC4519398 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature