Target-site resistance mutations (kdr and RDL), but not metabolic resistance, negatively impact male mating competiveness in the malaria vector Anopheles gambiae.

ABSTRACT: The implementation of successful insecticide resistance management strategies for malaria control is currently hampered by poor understanding of the fitness cost of resistance on mosquito populations, including their mating competiveness. To fill this knowledge gap, coupled and uncoupled Anopheles gambiae s.l. males (all M form (Anopheles coluzzii)) were collected from mating swarms in Burkina Faso. This multiple insecticide resistant population exhibited high 1014F kdr(R) allele frequencies (>60%) and RDL(R) (>80%) in contrast to the Ace-1(R) allele (<6%). Kdr heterozygote males were more likely to mate than homozygote resistant (OR=2.36; P<0.001), suggesting a negative impact of kdr on An. coluzzii mating ability. Interestingly, heterozygote males were also more competitive than homozygo

SUBMITTER: Platt N 

PROVIDER: S-EPMC4519523 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature