Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocio in Spain: Technical and Clinical Overview.

ABSTRACT: Hemophilia A and B are the most common hereditary hemorrhagic disorders, with an X-linked mode of inheritance. Reproductive options for the families affected with hemophilia, aiming at the prevention of the birth of children with severe coagulation disorders, include preimplantation genetic diagnosis (PGD). Here we present the results of our PGD Program applied to hemophilia, at the Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Rocío in Seville. A total of 34 couples have been included in our program since 2005 (30 for hemophilia A and 4 for hemophilia B). Overall, 60 cycles were performed, providing a total of 508 embryos. The overall percentage of transfers per cycle was 81.7% and the live birth rate per cycle ranged from 10.3 to 24.1% depe

SUBMITTER: Fernandez RM 

PROVIDER: S-EPMC4519537 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature