Invasive pneumococcal disease among children with and without sickle cell disease in the United States, 1998 to 2009.

ABSTRACT:

Background

Children with sickle cell disease (SCD) are at increased risk of illness and death from invasive pneumococcal disease (IPD). The introduction in 2000 of the 7-valent pneumococcal conjugate vaccine and penicillin prophylaxis for children with SCD has greatly reduced the incidence of IPD in this population. However, a recent report suggested an increase in cases of IPD in children with SCD.

Methods

Using data from Active Bacterial Core surveillance, we analyzed trends in hospitalizations, mortality and serotype among children with SCD compared with other children. We used neonatal screening data to estimate SCD population denominators for each Active Bacterial Core surveillance site.

Results

From 1998 to 2009, 3069 cases of IPD occurred among African-American

SUBMITTER: Payne AB 

PROVIDER: S-EPMC4519831 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature