A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women.

ABSTRACT:

Background

The fragile-site associated tumor suppressor (FATS, formerly known as C10orf90), a regulator of p53-p21 pathway has been involved in the onset of breast cancer. Recent data support the idea that the crosstalk between FATS and p53 may be of physiological importance for reproduction during evolution. The aim of the current study was to test the hypothesis that FATS genetic polymorphism can influence the risk of breast cancer.

Methods

We conducted population-based studies in two independent cohorts comprising 1 532 cases and 1 573 controls in Tianjin of North China, and 804 cases and 835 controls in Guangzhou of South China, coupled with functional validation methods, to investigate the role of FATS genetic variant in breast cancer risk.

Results

We identified

SUBMITTER: Song F 

PROVIDER: S-EPMC4520099 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature