A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation.

ABSTRACT: Organ transplant recipients face life-long immunosuppression and consequently are at high risk of comorbidities. Occasionally, kidney transplant recipients develop a state of targeted immune quiescence (operational tolerance) against an HLA-mismatched graft, allowing them to withdraw all immunosuppression and retain stable graft function while resuming immune responses to third-party antigens. Methods to better understand and monitor this state of alloimmune quiescence by transcriptional profiling may reveal a gene signature that identifies patients for whom immunosuppression could be titrated to reduce patient and graft morbidities. Therefore, we investigated 571 unique peripheral blood samples from 348 HLA-mismatched renal transplant recipients and 101 nontransplant controls in a four-st

SUBMITTER: Roedder S 

PROVIDER: S-EPMC4520154 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature