Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion.

ABSTRACT: Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal microbiota and have anti-inflammatory and histone deacetylase-inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expr

SUBMITTER: Andrade-Oliveira V 

PROVIDER: S-EPMC4520159 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature