The complex pattern of epigenomic variation between natural yeast strains at single-nucleosome resolution.

ABSTRACT:

Background

Epigenomic studies on humans and model species have revealed substantial inter-individual variation in histone modification profiles. However, the pattern of this variation has not been precisely characterized, particularly regarding which genomic features are enriched for variability and whether distinct histone marks co-vary synergistically. Yeast allows us to investigate intra-species variation at high resolution while avoiding other sources of variation, such as cell type or subtype.

Results

We profiled histone marks H3K4me3, H3K9ac, H3K14ac, H4K12ac and H3K4me1 in three unrelated wild strains of Saccharomyces cerevisiae at single-nucleosome resolution and analyzed inter-strain differences statistically. All five marks varied significantly at specific loci, bu

SUBMITTER: Filleton F 

PROVIDER: S-EPMC4520285 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature