Nonalcoholic fatty liver disease and vascular function: cross-sectional analysis in the Framingham heart study.

ABSTRACT:

Objective

Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk of cardiovascular disease; however, it is not known whether NAFLD contributes to cardiovascular disease independent of established risk factors. We examined the association between NAFLD and vascular function.

Approach and results

We conducted a cross-sectional study of 2284 Framingham Heart Study participants without overt cardiovascular disease who had liver fat attenuation measured on computed tomography and who had measurements of vascular function and covariates. We evaluated the association between NAFLD and vascular function using multivariable partial correlations adjusting for age, sex, cohort, smoking, diabetes mellitus, hyperlipidemia, hypertension, body mass index, and viscera

SUBMITTER: Long MT 

PROVIDER: S-EPMC4520415 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature