The c-MET Network as Novel Prognostic Marker for Predicting Bladder Cancer Patients with an Increased Risk of Developing Aggressive Disease.
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ABSTRACT:
SUBMITTER: Kim YW
PROVIDER: S-EPMC4520492 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
The c-MET Network as Novel Prognostic Marker for Predicting Bladder Cancer Patients with an Increased Risk of Developing Aggressive Disease.
Kim Young-Won YW Yun Seok Joong SJ Jeong Phildu P Kim Seon-Kyu SK Kim Seon-Young SY Yan Chunri C Seo Sung Phil SP Lee Sang Keun SK Kim Jayoung J Kim Wun-Jae WJ
PloS one 20150730 7
Previous studies have shown that c-MET is overexpressed in cases of aggressive bladder cancer (BCa). Identification of crosstalk between c-MET and other RTKs such as AXL and PDGFR suggest that c-MET network genes (c-MET-AXL-PDGFR) may be clinically relevant to BCa. Here, we examine whether expression of c-MET network genes can be used to identify BCa patients at increased risk of developing aggressive disease. In vitro analysis, c-MET knockdown suppressed cell proliferation, invasion, and migrat ...[more]
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