Removal of Different Classes of Uremic Toxins in APD vs CAPD: A Randomized Cross-Over Study.

ABSTRACT:

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Aim

In this study, we investigated, and this for the different classes of uremic toxins, whether increasing dialysate volume by shifting from continuous ambulatory peritoneal dialysis (CAPD) to higher volume automated peritoneal dialysis (APD) increases total solute clearance. ♦

Methods

Patients on peritoneal dialysis were randomized in a cross-over design to one 24-hour session of first a CAPD regimen (3*2 L of Physioneal 1.36% and 1*2 L of icodextrin) or APD (consisting of 5 cycles of 2 L Physioneal 1.36 and 1 cycle of 2 L Extraneal), and the other week the alternate regime, each patient serving as his/her own control. Dialysate, blood and urine samples were collected and frozen for later batch analysis of concentrations of urea, creatinine, phosphorus,

SUBMITTER: Eloot S 

PROVIDER: S-EPMC4520726 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature