APOE ε4 and lipid levels affect risk of recurrent nonlobar intracerebral hemorrhage.

ABSTRACT:

Objective

Genetic variants ε2/ε4 within the APOE gene are established risk factors for lobar intracerebral hemorrhage (ICH). Published preliminary data suggest a potential role for APOE ε4 in risk of nonlobar ICH. We therefore investigated the role of APOE in recurrent nonlobar ICH, and sought to clarify whether effects of APOE on circulating lipids mediate this association.

Methods

Three hundred sixty-three survivors of nonlobar ICH were followed prospectively for ICH recurrence, with APOE genotype determined at enrollment. All participants had clinical, demographic, and laboratory data captured at time of index ICH and during follow-up. Using a multivariate model, we performed association and interaction analyses of the relationships among APOE genotype, lipid levels, and

SUBMITTER: Raffeld MR 

PROVIDER: S-EPMC4520812 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature