Temporal trends in safety of carotid endarterectomy in asymptomatic patients: systematic review.

ABSTRACT:

Objective

To systematically review temporal changes in perioperative safety of carotid endarterectomy (CEA) in asymptomatic individuals in trial and registry studies.

Methods

The MEDLINE and EMBASE databases were searched using the terms "carotid" and "endarterectomy" and "asymptomatic" from 1947 to August 23, 2014. Articles dealing with 50%-99% stenosis in asymptomatic individuals were included and low-volume studies were excluded. The primary endpoint was 30-day stroke or death and the secondary endpoint was 30-day all-cause mortality. Statistical analysis was performed using random-effects meta-regression for registry data and for trial data graphical interpretation alone was used.

Results

Six trials (n = 4,431 procedures) and 47 community registries (n = 204,622 p

SUBMITTER: Munster AB 

PROVIDER: S-EPMC4520814 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature