The impact of HIV on presentation and outcome of bacterial sepsis and other causes of acute febrile illness in Gabon.

ABSTRACT:

Purpose

HIV, bacterial sepsis, malaria, and tuberculosis are important causes of disease in Africa. We aimed to determine the impact of HIV on the presentation, causes and outcome of bacterial sepsis and other acute febrile illnesses in Gabon, Central Africa.

Methods

We performed a prospective observational study in new adult admissions with fever or hypothermia (≥ 38 or <36 °C). Blood cultures, as well as HIV and malaria testing were performed in all patients.

Results

We enrolled 382 patients, including 77 (20.2%) with HIV infection. Malaria was the most frequent diagnosis (n = 130, 34%), and was associated with a more severe presentation in HIV patients. Sepsis was also common (n = 107, 28%), including 29 (7.6%) patients with culture confirmed bacterial bloodstream

SUBMITTER: Huson MA 

PROVIDER: S-EPMC4521089 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature