Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps.

ABSTRACT: Cancerogenesis is driven by mutations leading to aberrant functioning of a complex network of molecular interactions and simultaneously affecting multiple cellular functions. Therefore, the successful application of bioinformatics and systems biology methods for analysis of high-throughput data in cancer research heavily depends on availability of global and detailed reconstructions of signalling networks amenable for computational analysis. We present here the Atlas of Cancer Signalling Network (ACSN), an interactive and comprehensive map of molecular mechanisms implicated in cancer. The resource includes tools for map navigation, visualization and analysis of molecular data in the context of signalling network maps. Constructing and updating ACSN involves careful manual curation of molec

SUBMITTER: Kuperstein I 

PROVIDER: S-EPMC4521180 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature