MiR-628, a microRNA that is induced by Toll-like receptor stimulation, regulates porcine innate immune responses.

ABSTRACT: Mammalian innate and acquired immune responses involve a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanism. MicroRNAs have been implicated as a negative regulator for diverse biological events including immune responses. However, the involvement of miRNAs in regulating the immune responses is just beginning to be explored. Here, we characterized the expression profiling of 375 microRNAs in porcine monocytes induced by lipopolysaccharide (LPS), and result shows that several of them are endotoxin-responsive genes. Through promoter analysis, the miR-628 was found to be a NF-κB dependent gene. Importantly, miR-628 was predicted to base-pair with sequences in the 3'-UTR of the myeloid differentiation protein 88 (MyD88) gene. A

SUBMITTER: Jun H 

PROVIDER: S-EPMC4521185 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature