Simulated unbound structures for benchmarking of protein docking in the DOCKGROUND resource.

ABSTRACT:

Background

Proteins play an important role in biological processes in living organisms. Many protein functions are based on interaction with other proteins. The structural information is important for adequate description of these interactions. Sets of protein structures determined in both bound and unbound states are essential for benchmarking of the docking procedures. However, the number of such proteins in PDB is relatively small. A radical expansion of such sets is possible if the unbound structures are computationally simulated.

Results

The DOCKGROUND public resource provides data to improve our understanding of protein-protein interactions and to assist in the development of better tools for structural modeling of protein complexes, such as docking algorithms and scor

SUBMITTER: Kirys T 

PROVIDER: S-EPMC4521349 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature