Phytoestrogens and risk of prostate cancer: a meta-analysis of observational studies.

ABSTRACT:

Background

Epidemiologic studies have reported various results relating phytoestrogens to prostate cancer (PCa). The aim of this study was to provide a comprehensive meta-analysis on the extent of the possible association between phytoestrogens (including consumption and serum concentration) and the risk of PCa.

Methods

Eligible studies were retrieved via both computer searches and review of references. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated with random effects models.

Results

A total of 11 studies (2 cohort and 9 case-control studies) on phytoestrogen intake and 8 studies on serum concentration were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest

SUBMITTER: He J 

PROVIDER: S-EPMC4521376 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature