Calcium kinetics during bed rest with artificial gravity and exercise countermeasures.

ABSTRACT:

Unlabelled

We assessed the potential for countermeasures to lessen the loss of bone calcium during bed rest. Subjects ingested less calcium during bed rest, and with artificial gravity, they also absorbed less calcium. With exercise, they excreted less calcium. To retain bone during bed rest, calcium intake needs to be maintained.

Introduction

This study aims to assess the potential for artificial gravity (AG) and exercise (EX) to mitigate loss of bone calcium during space flight.

Methods

We performed two studies: (1) a 21-day bed rest (BR) study with subjects receiving 1 h/day AG (n = 8) or no AG (n = 7) and (2) a 28-day BR study with 1 h/day resistance EX (n = 10) or no EX (n = 3). In both studies, stable isotopes of Ca were administered orally and intravenously, at

SUBMITTER: Smith SM 

PROVIDER: S-EPMC4521405 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature