HaploPOP: a software that improves population assignment by combining markers into haplotypes.

ABSTRACT:

Background

In ecology and forensics, some population assignment techniques use molecular markers to assign individuals to known groups. However, assigning individuals to known populations can be difficult if the level of genetic differentiation among populations is small. Most assignment studies handle independent markers, often by pruning markers in Linkage Disequilibrium (LD), ignoring the information contained in the correlation among markers due to LD.

Results

To improve the accuracy of population assignment, we present an algorithm, implemented in the HaploPOP software, that combines markers into haplotypes, without requiring independence. The algorithm is based on the Gain of Informativeness for Assignment that provides a measure to decide if a pair of markers should b

SUBMITTER: Duforet-Frebourg N 

PROVIDER: S-EPMC4521458 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature