Serum biomarkers of treatment response within a randomized clinical trial for pulmonary tuberculosis.

ABSTRACT:

Rationale

Biomarkers for monitoring response to anti-tuberculosis treatment are needed. We explored immune markers previously published as having predictive capability for 8 week culture status in 39 adults enrolled in a clinical trial in Kampala, Uganda.

Methods

We consecutively selected 20 HIV-negative pulmonary TB subjects with positive cultures, and 19 subjects with negative cultures at the end of intensive phase therapy. At baseline and after 8 weeks, serum was assayed for nine cytokines and soluble cytokine receptors using multiplexed platforms or ELISA. We evaluated their association with week 8 culture status first using single-variable logistic models, then using cross-validated estimates of the C-statistic, a measure of discrimination, of candidate models including

SUBMITTER: Jayakumar A 

PROVIDER: S-EPMC4521594 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature