Quantitative assessment of pre-miR-218 rs11134527 polymorphism and cancer risk in Chinese population.

ABSTRACT:

Background

Accumulated studies have evaluated the association of pre-miR-218 rs11134527 polymorphism with cancer risk in Chinese population. However, the results remain controversial.

Methods

To derive a more precise and more comprehensive estimation of the relationship, six studies focused on Chinese population were included for the pooled analysis for pre-miR-218 rs11134527 polymorphism using odds ratios (ORs) with 95% confidence intervals (CIs).

Results

Pre-miR-218 rs11134527 polymorphism was associated with cancer risk (G versus A, OR =0.93, 95% CI: 0.88-0.98; GG versus AG + AA, OR =0.88, 95% CI: 0.79-0.97; GG versus AA, OR =0.85, 95% CI: 0.76-0.96). In the stratified analysis by cancer type, the pre-miR-218 rs11134527 polymorphism was only associated with the ris

SUBMITTER: Zhao H 

PROVIDER: S-EPMC4521665 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature