Unique genomic profile of fibrolamellar hepatocellular carcinoma.

ABSTRACT:

Background & aims

Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer that develops in children and young adults without cirrhosis. Little is known about its pathogenesis, and it can be treated only with surgery. We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors.

Methods

By using 78 clinically annotated FLC samples, we performed whole-transcriptome (n = 58), single-nucleotide polymorphism array (n = 41), and next-generation sequencing (n = 48) analyses; we also assessed the prevalence of the DNAJB1-PRKACA fusion transcript associated with this cancer (n = 73). We performed class discovery using non-negative matrix factorization, and functional annotation using gene-set enrichme

SUBMITTER: Cornella H 

PROVIDER: S-EPMC4521774 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature