Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein.

ABSTRACT: Acinetobacter baumannii is an important nosocomial pathogen, causing a variety of opportunistic infections of the skin, soft tissues and wounds, urinary tract infections, secondary meningitis, pneumonia and bacteremia. Over 63% of A. baumannii infections occurring in the United States are caused by multidrug resistant isolates, and pan-resistant isolates have begun to emerge that are resistant to all clinically relevant antibiotics. The complement system represents the first line of defense against invading pathogens. However, many A. baumannii isolates, especially those causing severe bacteremia are resistant to complement-mediated killing, though the underlying mechanisms remain poorly understood. Here we show for the first time that A. baumannii binds host-derived plasminogen and we ide

SUBMITTER: Koenigs A 

PROVIDER: S-EPMC4521846 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature