Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart.

ABSTRACT:

Background

Despite modern pharmacotherapy and advanced implantable cardiac devices, overall prognosis and quality of life of HF patients remain poor. This is in part due to insufficient patient stratification and lack of individualized therapy planning, resulting in less effective treatments and a significant number of non-responders.

Methods and results

State-of-the-art clinical phenotyping was acquired, including magnetic resonance imaging (MRI) and biomarker assessment. An individualized, multi-scale model of heart function covering cardiac anatomy, electrophysiology, biomechanics and hemodynamics was estimated using a robust framework. The model was computed on n=46 HF patients, showing for the first time that advanced multi-scale models can be fitted consistently on lar

SUBMITTER: Kayvanpour E 

PROVIDER: S-EPMC4521877 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature