Telomere Length in Peripheral Blood Leukocytes Is Associated with Severity of Biliary Atresia.

ABSTRACT:

Objective

The purpose of this study was to investigate the association of telomere length in peripheral blood leukocytes with the severity of biliary atresia (BA).

Methods

One hundred and fourteen BA patients and 114 age-matched healthy controls were enrolled. Relative telomere length (RTL) was assessed using a quantitative real-time polymerase chain reaction. Multivariate regression analysis was used to estimate RTL as an independent risk factor of BA. Receiver operating characteristic curve analysis was used to calculate the accuracy of biomarkers in the prediction of liver cirrhosis.

Results

BA patients had significantly shorter telomeres than healthy controls (p < 0.0001). The RTL in BA patients with jaundice was considerably lower than that of patients without ja

SUBMITTER: Udomsinprasert W 

PROVIDER: S-EPMC4521951 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature