Connectome signatures of neurocognitive abnormalities in euthymic bipolar I disorder.

ABSTRACT:

Objectives

Connectomics have allowed researchers to study integrative patterns of neural connectivity in humans. Yet, it is unclear how connectomics may elucidate structure-function relationships in bipolar I disorder (BPI). Expanding on our previous structural connectome study, here we used an overlapping sample with additional psychometric and fMRI data to relate structural connectome properties to both fMRI signals and cognitive performance.

Methods

42 subjects completed a neuropsychological (NP) battery covering domains of processing speed, verbal memory, working memory, and cognitive flexibility. 32 subjects also had fMRI data performing a Go/NoGo task.

Results

Bipolar participants had lower NP performance across all domains, but only working memory reached stati

SUBMITTER: Ajilore O 

PROVIDER: S-EPMC4522047 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature