Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.

ABSTRACT:

Rationale

The role of Parkin in hearts is unclear. Germ-line Parkin knockout mice have normal hearts, but Parkin is protective in cardiac ischemia. Parkin-mediated mitophagy is reportedly either irrelevant, or a major factor, in the lethal cardiomyopathy evoked by cardiac myocyte-specific interruption of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.

Objective

To understand the role of Parkin-mediated mitophagy in normal and mitochondrial fission-defective adult mouse hearts.

Methods and results

Parkin mRNA and protein were present at low levels in normal mouse hearts, but were upregulated after cardiac myocyte-directed Drp1 gene deletion in adult mice. Alone, forced cardiac myocyte Parkin overexpression activated mitophagy without adverse effects. L

SUBMITTER: Song M 

PROVIDER: S-EPMC4522211 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature