Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech.

ABSTRACT: The consensus criteria for the diagnosis and classification of primary progressive aphasia (PPA) have served as an important tool in studying this group of disorders. However, a large proportion of patients remain unclassifiable whilst others simultaneously meet criteria for multiple subtypes. We prospectively evaluated a large cohort of patients with degenerative aphasia and/or apraxia of speech using multidisciplinary clinical assessments and multimodal imaging. Blinded diagnoses were made using operational definitions with important differences compared to the consensus criteria. Of the 130 included patients, 40 were diagnosed with progressive apraxia of speech (PAOS), 12 with progressive agrammatic aphasia, 9 with semantic dementia, 52 with logopenic progressive aphasia, and 4 with pro

SUBMITTER: Botha H 

PROVIDER: S-EPMC4522343 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature