Dose timing of D-cycloserine to augment cognitive behavioral therapy for social anxiety: Study design and rationale.

ABSTRACT: The use of D-cycloserine (DCS) as a cognitive enhancer to augment exposure-based cognitive-behavioral therapy (CBT) represents a promising new translational research direction with the goal to accelerate and optimize treatment response for anxiety disorders. Some studies suggest that DCS may not only augment extinction learning but could also facilitate fear memory reconsolidation. Therefore, the effect of DCS may depend on fear levels reported at the end of exposure sessions. This paper presents the rationale and design for a randomized controlled trial examining the relative efficacy of tailoring DCS administration based on exposure success (i.e. end fear levels) during a 5-session group CBT protocol for social anxiety disorder (n = 156). Specifically, tailored post-session DCS administr

SUBMITTER: Hofmann SG 

PROVIDER: S-EPMC4522368 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature