Family history of cancer and the risk of squamous cell carcinoma of oesophagus: a case-control study in Kashmir, India.

ABSTRACT:

Background

Only a few studies have examined the association between family history of cancer (FHC) and the risk of oesophageal squamous cell carcinoma (ESCC) in high incidence areas of ESCC. We conducted a case-control study to evaluate the relationship between FHC and ESCC risk in Kashmir, India, with analysis of detailed epidemiological data and information on multiple gene polymorphisms.

Methods

We collected detailed information on FHC and a number of socio-demographic and lifestyle factors, and also obtained blood samples for genetic analysis from 703 histopathologically confirmed ESCC cases and 1664 individually matched controls. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results

Partici

SUBMITTER: Bhat GA 

PROVIDER: S-EPMC4522628 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature