Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?

ABSTRACT:

Background

Metformin, statin and aspirin use seem associated with decreased mortality in cancer patients, though, without adjusting for one another. Independent associations of these drugs with overall mortality after colorectal cancer (CRC) diagnosis within glucose-lowering drugs (GLDs) users were assessed.

Methods

Patients starting GLDs before CRC diagnosis (1998-2011) were selected from the Eindhoven Cancer Registry linked with the PHARMO Database Network. The Cox regression model, with time since CRC diagnosis, included time-dependent variables of cumulative exposure to metformin, statins and aspirin after cancer diagnosis and time-dependent ever-never terms for drug exposure.

Results

A total of 1043 patients used GLDs before CRC diagnosis; 666 (64%) used metformi

SUBMITTER: Zanders MM 

PROVIDER: S-EPMC4522645 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature